反应详情

A mixture of 22.0 g (0.075 mole) of N-benzoyl-4-phenoxymethylpiperidine, 25 ml of 10 N aqueous sodium hydroxide solution and 175 ml of ethanol is heated under reflux for 18 hours. The reaction mixture is then evaporated in a vacuum and the residue is taken up in diethyl ether, washed with water, dried over anhydrous sodium sulfate and the solvent then evaporated off. There are obtained 12.0 g of 4-phenoxymethylpiperidine (84% of theory); m.p. 42°-43° C.

1. temperatureis heated
2. temperatureunder reflux for 18 hours
3. customThe reaction mixture is then evaporated in a vacuum
4. washwashed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customthe solvent then evaporated off