Potassium Hydroxide → 1-(2-(4-Fluorophenyl)ethyl)piperazine

Participants

Reaction Steps

As in the foregoing Example, 48.6 g of the carbamate is hydrolyzed with 50 g potassium hydroxide in 50 ml ethanol at 120° C. Processing gives 21.5 g (60%) 1-[2-(4-fluorophenyl)ethyl]piperazine with a b.p. of 142° C./3 Torr. It may be transformed into a dimaleate crystallizing from 95% ethanol as a hemihydrate and melting at 164.5°-166.5° C.

Provenance & Evidence