Hydrochloric Acid → HCID 13050677, compound

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Reaction Steps

Powdered anhydrous calcium chloride (9 g) was added to a solution of 9.4 g of the foregoing alcohol in 120 ml of benzene and the suspension saturated over 2 hours under stirring with anhydrous hydrogen chloride. After 1 hour standing, the mixture was filtered, and the filtrate evaporated under reduced pressure. The required 10-chloro-8-ethyl-3-fluoro-10,11-dihydrodibenzo(b,f)thiepin was obtained in an almost theoretical yield (10.0 g); crystallization from petroleum ether yielded the pure substance melting at 68°-70° C.

Provenance & Evidence