Water → HCID 12756953, compound

Participants

Reaction Steps

A solution of 19 g [4-fluoro-2-(4-nitrophenylthio)phenyl] acetic acid in 60 ml of acetic acid was slowly added dropwise into a boiling mixture of 300 ml water and 30 g iron powder. The mixture was then stirred and refluxed for 6 hours. After cooling, 200 ml of a 20% sodium hydroxide solution were added, the solution filtered and the filtrate acidified with acetic acid. After standing overnight, the separated product was filtered, washed with a small quantity of water and dried in vacuo. There were obtained 9.5 g of crude [2-(4-aminophenylthio)-4-fluorophenyl]acetic acid melting at 151°-155° C. After a single crystallization from a mixture of benzene and petroleum ether, the product was pure and melted at 154°-156° C.

Provenance & Evidence