反应详情

A mixture of 20 g of 10-chloro-3-fluoro-8-isopropyl-10,11-dihydrodibenzo(b,f)thiepin, 21 g of 1-(ethoxycarbonyl)piperazine and 30 ml of chloroform is refluxed for 5 hours. After cooling, it is diluted with chloroform, the solution thoroughly washed with water, dried with potassium carbonate and after filtration evaporated under reduced pressure. The residue (27 g, 96%) is a crude glassy 10-(ethoxycarbonylpiperazino)-3-fluoro-8-isopropyl-10,11-dihydrodibenzo(b,f)thiepin which is used for hydrolysis in this state without further purification.

1. temperatureis refluxed for 5 hours
2. temperatureAfter cooling
3. washthe solution thoroughly washed with water
4. dry with materialdried with potassium carbonate
5. filtrationafter filtration
6. customevaporated under reduced pressure
7. customis used for hydrolysis in this state without further purification