反应详情

A mixture of 6.9 parts of 3,4-diaminobenzenemethanol, 8.3 parts of ethyl butanimidate hydrochloride and 80 parts of ethanol is stirred first for 2 hours at room temperature and further for 2 hours at reflux. The reaction mixture is evaporated and the residue is stirred in water. The whole is alkalized with ammonium hydroxide and the product is extracted with 4-methyl-2-pentanone. The extract is dried, filtered and evaporated, yielding 6.2 parts of 2-propyl-1H-benzimidazole-5-methanol as a residue.

1. temperatureat reflux
2. customThe reaction mixture is evaporated
3. stirringthe residue is stirred in water
4. extractionthe product is extracted with 4-methyl-2-pentanone
5. customThe extract is dried
6. filtrationfiltered
7. customevaporated