Benzhydrylpiperazine → HCID 20298725, compound

Participants

Reaction Steps

A mixture of 13.9 parts of 1-(diphenylmethyl)piperazine, 8.35 parts of 2-bromo-1-(4-chloro-3-nitrophenyl)ethanone and 40 parts of 2-propanone is stirred for 30 minutes at room temperature. The formed precipitate is filtered off and 210 parts of 2,2'-oxybispropane are added to the filtrate. The whole is treated with activated charcoal. The latter is filtered off and an excess of 2-propanol, previously saturated with gaseous hydrogen chloride, is added to the filtrate. The formed hydrochloride salt is filtered off, stirred in 80 parts of 2-propanol, filtered off again and crystallized from ethanol. The product is filtered off and recrystallized from 2-methoxyethanol, yielding 6.4 parts of 1-(4-chloro-3-nitrophenyl)-2-[4-(diphenylmethyl)-1-piperazinyl]ethanone dihydrochloride; mp. 165° C.

Provenance & Evidence