Acetic Acid → HCID 20298778, compound

Participants

Reaction Steps

To a stirred mixture of 5.2 parts of 1-(4-chloro-3-nitrophenyl)-2-[4-(diphenylmethyl)-1-piperazinyl]ethanone dihydrochloride in 40 parts of methanol are added portionwise 0.76 parts of sodium borohydride. Upon completion, stirring is continued for 30 minutes at room temperature. The reaction mixture is decomposed by the addition of a mixture of 2 parts of acetic acid and 10 parts of water. The solvent is evaporated and 50 parts of water are added to the residue. The whole is alkalized with ammonium hydroxide. The precipitated product is filtered off, washed with water and with a small amount of 2-propanol, and crystallized from ethanol, yielding 4.3 parts (95.1%) of α-(4-chloro-3-nitrophenyl)-4-(diphenylmethyl)-1-piperazineethanol; mp. 163.4° C.

Provenance & Evidence