Benzoyl chloride → HCID 86736744, compound

Participants

Reaction Steps

To a stirred mixture of 5.03 parts of 5-[4-(diphenylmethyl)-1-piperazinylmethyl]-2-phenyl-1H-benzimidazole-1-ethanol and 50 parts of pyridine are added dropwise 3 parts of benzoyl chloride at room temperature. Upon completion, stirring at room temperature is continued for 2 hours. The reaction mixture is evaporated and water is added to the residue. The product is extracted with dichloromethane. The extract is washed with water, dried, filtered and evaporated. The residue is crystallized from 20 parts of 2-propanol. The product is filtered off, washed with 2-propanol and with 2,2'-oxybispropane and dried, yielding 4 parts (66.5%) of [2-{5-[4-(diphenylmethyl)-1-piperazinylmethyl]-2-phenyl-1H-benzimidazol-1-yl}ethyl]benzoate; mp. 164.1° C.

Provenance & Evidence