HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoisovaleric acid → N-(2-fluoro-4-chlorophenyl)valine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoisovaleric acid | HCID 11268 | — |
| Reactant | 4-Chloro-2-fluoroaniline | HCID 93898 | — |
| Product | N-(2-fluoro-4-chlorophenyl)valine | HCID 54022058 | — |
Reaction Steps
Following the procedure of Example 17, N-(2-fluoro-4-chlorophenyl)valine (0.79 g) is reacted with α-ethynyl-m-phenoxybenzyl bromide (0.39 g) to yield the α-ethynyl-m-phenoxybenzyl ester of N-(2-fluoro-4-chlorophenyl)valine, MS m/e 451 (M+). N-(2-fluoro-4-chlorophenyl)valine is prepared from 2-fluoro-4-chloroaniline and α-bromoisovaleric acid using the procedure of Example 17.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243819 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-9d1af699e82d41df954b1ed8d0a82ffd |
| Source note | uspto-grants-1981_01 |