HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoisovaleric acid → N-(2-fluoro-4-methylphenyl)valine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoisovaleric acid | HCID 11268 | — |
| Reactant | 2-Fluoro-4-methylaniline | HCID 67984 | — |
| Reactant | alpha-Ethynyl-m-phenoxybenzyl bromide | HCID 20482714 | — |
| Product | N-(2-fluoro-4-methylphenyl)valine | HCID 54059120 | — |
Reaction Steps
N-(2-fluoro-4-methylphenyl)valine is prepared from α-bromoisovaleric acid and 2-fluoro-4-methylaniline and then reacted with α-ethynyl-m-phenoxybenzyl bromide to yield the α-ethynyl-m-phenoxybenzyl ester of N-(2-fluoro-4-methylphenyl)valine, MS m/e 431 (M+, 180).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243819 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-b4881b8293044127922b0054f21e02f1 |
| Source note | uspto-grants-1981_01 |