HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → N-formyl,N-(4-chlorophenyl)valine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Acetic-formic anhydride | HCID 75269 | — |
| Reactant | N-(p-chlorophenyl)valine | HCID 13796078 | — |
| Product | N-formyl,N-(4-chlorophenyl)valine | HCID 57019758 | — |
| Product | N-acetylformyl,N-(4-chlorophenyl)valine | HCID 57070001 | — |
Reaction Steps
A mixture of the m-phenoxybenzyl ester of N-(4-chlorophenyl)valine (1.22 mmole), acetic formic anhydride in acetic acid (23.8 mmole, 2.1 g) and formic acid (1.5 ml) is stirred overnight at RT under nitrogen. The reaction product is concentrated and then subjected to prep. TLC eluting with 20% ethylacetate/hexane to yield the m-phenoxybenzyl ester of N-formyl,N-(4-chlorophenyl)valine, MS m/e 437 (M+, 8.1), 182 (100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243819 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-bdfe1b327dba4b8d96f0900e06ee5db7 |
| Source note | uspto-grants-1981_01 |