反应详情

To the potassium salt of α-bromoisovaleric acid (1.42 g) is added 4-bromo-2-fluoroaniline (1.9 g). The mixture is heated at 125° under nitrogen for 3.5 hr and then cooled to RT. The reaction product is poured into 2 M NaOH and ether/chloroform. The basic phase is separated and acidified with conc. HCl and then extracted into ether, washed with saturated NaCl solution, dried over calcium sulfate and evaporated to yield N-(4-bromo-2-fluorophenyl)valine.

1. temperatureThe mixture is heated at 125° under nitrogen for 3.5 hr
2. customThe basic phase is separated
3. extractionextracted into ether
4. washwashed with saturated NaCl solution
5. dry with materialdried over calcium sulfate
6. customevaporated