Sodium Hydroxide → HCID 20296042, compound

HRID 1389398Notes

Reaction equation

HRID 1389398 reaction equation
[CH3:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:3]=1[O:4][CH2:5][C:6]([NH2:8])=O.[OH-].[Na+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.C(Cl)(Cl)Cl>[CH3:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[C:3]=1[O:4][CH2:5][C:6]#[N:8]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 926882HCID 926882, compound

Product 1

HCID 20296042HCID 20296042, compound

Reagents, catalysts & solvents 2

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 6212ChloroformSolvent

Procedure

500 Milligrams of benzyltriethyl ammonium chloride and 13.4 g of 2,6-dimethylphenoxyacetamide was added to a heterogeneously mixed solution of 182 ml of chloroform and 60 g of 50% sodium hydroxide aqueous solution, and the solution was stirred vigorously at room temperature for two hours. After completion of reaction, the chloroform phase was separated, and the reaction solution was washed with water, dried over anhydrous magnesium sulfate, and freed from the solvent to obtain an oily substance. The distillation under reduced pressure of the reaction mixture gave 9.7 g of a distillate, 2,6-dimethylphenoxyacetonitrile, b.p. 86°-88° C./0.6 mmHg.

Workup

  1. customAfter completion of reaction
  2. customthe chloroform phase was separated
  3. washthe reaction solution was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customto obtain an oily substance
  6. distillationThe distillation under reduced pressure of the reaction mixture

Sources & evidence

ORD record
ord-38813e22b56f4e008916d7c0bf686c4c
Source dataset
uspto-grants-1981_01
Patent number
US04244731

Reaction notes

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