Dimethylformamide → HCID 178526062, compound

Participants

Reaction Steps

To a solution of dimethylformamide (47.5 kg) containing pyridine (4.7 kg), there were added 4-hydroxy-1,5-naphthyridine-3-carboxylic acid (2.8 kg) and N-hydroxy-succinimide (2.2 kg). To the mixture, there was dropwise added thionyl chloride (2.1 kg) while stirring at room temperature, and stirring was continued for 5 hours at the same temperature. The precipitated crystals were collected by filtration, washed with acetone and dried under reduced pressure to give 4.3 kg of N-(4-hydroxy-1,5-naphthyridine-3-carbonyloxy)succinimide. Purity, 97%

Provenance & Evidence