Bis(dichloromethyl) ether → alpha-Sulfo-3-(chloromethyl)-4-hydroxybenzeneacetic acid

HRID 1389404Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1389404
[S:1]([CH:5]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[C:6]([OH:8])=[O:7])([OH:4])(=[O:3])=[O:2].[Cl:16][CH:17](OC(Cl)Cl)Cl>S(=O)(=O)(O)O>[S:1]([CH:5]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH2:17][Cl:16])[CH:10]=1)[C:6]([OH:8])=[O:7])([OH:4])(=[O:3])=[O:2]

Komponenten

4

Edukt 2

HCID 558102Bis(dichloromethyl) etherHCID 3373694(4-Hydroxy-phenyl)-sulfo-acetic acid

Produkt 1

HCID 20296128alpha-Sulfo-3-(chloromethyl)-4-hydroxybenzeneacetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

α-Sulfo-4-hydroxybenzeneacetic acid, 0.3 mole, is dissolved in aqueous sulfuric acid (50%). One equivalent of dichloromethyl ether is added to the solution maintained at between 35° to 45° C. Hydrogen chloride is then bubbled through this reaction mixture for 3 hours. The desired compound is recovered by pouring the reaction mixture into water and extracting the title compound with ethyl acetate. The ethyl acetate is dried over magnesium sulfate. The magnesium sulfate is removed by filtration and evaporation of the ethyl acetate gives the title compound.

Aufarbeitung

  1. temperaturemaintained at between 35° to 45° C
  2. customHydrogen chloride is then bubbled through this reaction mixture for 3 hours
  3. customThe desired compound is recovered
  4. additionby pouring the reaction mixture into water
  5. extractionextracting the title compound with ethyl acetate
  6. dry with materialThe ethyl acetate is dried over magnesium sulfate
  7. customThe magnesium sulfate is removed by filtration and evaporation of the ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-d39adf4eb1f1411ba93e698d86ef881b
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04244885

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