Acetic Acid → 32507-69-0

HRID 1389405Notes

Reaction equation

HRID 1389405 reaction equation
[NH2:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].C(O)(=O)C.[O-:17][C:18]#[N:19].[K+].[Cl-].[Na+]>O>[NH2:19][C:18]([NH:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4])=[O:17]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 5234Sodium ChlorideHCID 921434-HydroxyphenylglycineHCID 11378442Potassium cyanate

Product 1

HCID 57894132507-69-0

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To about 0.15 mole of α-amino-4-hydroxybenzeneacetic acid dissolved in 700 ml of water and 0.2 mole of glacial acetic acid is added about 0.2 mole of potassium cyanate. The resulting mixture is stirred at room temperature for about 30 minutes. The reaction mixture is saturated with sodium chloride and then extracted with ethyl acetate. The ethyl acetate is washed with water, dried over magnesium sulfate, filtered and evaporated to give α-(aminocarbonyl)amino-4-hydroxybenzeneacetic acid.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe ethyl acetate is washed with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-62133760cc1c441bb3b74764f3397eda
Source dataset
uspto-grants-1981_01
Patent number
US04244885

Reaction notes

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