Water → HCID 20296135, compound

HRID 1389406Notes

Reaction equation

HRID 1389406 reaction equation
[NH2:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4].O.[CH3:14][N:15]=[C:16]=[O:17].[Cl-].[Na+]>C(O)(=O)C>[CH3:14][NH:15][C:16]([NH:1][CH:2]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[C:3]([OH:5])=[O:4])=[O:17]

Participants

6

Reactant 4

HCID 962WaterHCID 5234Sodium ChlorideHCID 12228Methyl IsocyanateHCID 921434-Hydroxyphenylglycine

Product 1

HCID 20296135HCID 20296135, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 0.1 mole of α-amino-4-hydroxybenzeneacetic acid dissolved in 500 ml of water containing 0.05 mole of acetic acid is added 0.11 mole of methyl isocyanate. This mixture is stirred for 30 minutes at room temperature. The reaction mixture is saturated with sodium chloride and then extracted with ethyl acetate. The ethyl acetate is washed with water, dried over magnesium sulfate, filtered and evaporated to give the title compound.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe ethyl acetate is washed with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-39271196d02d405cbf4b49990007de56
Source dataset
uspto-grants-1981_01
Patent number
US04244885

Reaction notes

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