2-Hydrazinopyridine → HCID 12764908, compound

HRID 1389443Notes

Reaction equation

HRID 1389443 reaction equation
[NH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1)[NH2:2].[C:9]([O-])([O-])(OCC)[CH3:10].CC1N2C([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=CC=CC2=NN=1>>[CH3:9][C:10]1[N:4]2[CH2:5][CH:6]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:7][CH2:8][C:3]2=[N:1][N:2]=1

Participants

4

Reactant 3

HCID 786452-HydrazinopyridineHCID 20296332HCID 20296332, compoundHCID 86598186Ethyl ortho-acetate

Product 1

HCID 12764908HCID 12764908, compound

Procedure

A solution of 0.85 g. of the above hydrazinopyridine in 10 ml. of ethyl orthoacetate is heated at reflux for 5 hours. On cooling pale yellow plates are separated which are washed with hexane to give 0.55 g. of 3-methyl-5-phenyl-1,2,4-triazolo[4,3-a]pyridine, m.p. 182°-184° C.

Workup

  1. temperatureat reflux for 5 hours
  2. temperatureOn cooling pale yellow plates
  3. customare separated which
  4. washare washed with hexane
  5. customto give 0.55 g

Sources & evidence

ORD record
ord-83115b3b0b9c41ceb88f0d4600fda3df
Source dataset
uspto-grants-1981_01
Patent number
US04244953

Reaction notes

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