Chloroacetic Acid → HCID 178526159, compound

Participants

Reaction Steps

72.0 g. (0.76 mole) of α-chloroacetic acid, 40.0 g. of sodium bicarbonate, and 2 l. of water were placed in a 4 l. beaker and 110 g. (0.76 mole) of p-chlorobenzenethiol and 30 g. of sodium hydroxide in 200 ml. of water were added. After 0.5 to 2 hrs. on a steam bath the mixture was cooled, filtered, and the filtrate treated with 41 ml. of sulfuric acid (previously diluted to 100 ml. with water). The product was collected on a Buchner funnel and purified by dissolving in dilute aqueous sodium hydroxide, then treated with activated charcoal, filtered, and acidified. There was obtained in this manner, 78.5% yield of the final product, m.p. 105.5°-106° C.

Provenance & Evidence