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Hydrochloric Acid → 8-Carbobenzyloxy-1-oxa-3,8-diazaspiro[4.5]decan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Benzyl chloroformate | HCID 10387 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1-Oxa-3,8-diazaspiro(4.5)decan 2-one | HCID 12954114 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 8-Carbobenzyloxy-1-oxa-3,8-diazaspiro[4.5]decan-2-one | HCID 13016595 | 81.5% |
反応手順
To a mixture of 9.5 g 1-oxa-3,8-diazaspiro[4.5]decan-2-one and 75 ml water, at 0°, are added 6.3 g sodium bicarbonate and 10.9 g benzyl chloroformate. The mixture is stirred 18 hours at 0°, acidified with 10 N hydrochloric acid and stirred four hours at room temperature. The mixture is extracted with three 50 ml portions of dichloromethane. Removal of solvent affords 14.4 g 8-carbobenzyloxy-1-oxa-3,8-diazaspiro[4.5]decan-2-one, mp 126°-128°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04244961 |
| 出典データセット | uspto-grants-1981_01 |
| ORD ID | ord-046d34215ee246058fa1a15eea9172e5 |
| 出典メモ | uspto-grants-1981_01 |