HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 8-[2-Hydroxy-3-(2-methoxyphenoxy)propyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-Oxa-3,8-diazaspiro(4.5)decan 2-one | HCID 12954114 | — |
| Reactant | HCID 86737432 | HCID 86737432 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 8-[2-Hydroxy-3-(2-methoxyphenoxy)propyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | HCID 13016648 | 86.7% |
Reaction Steps
A mixture of 3.12 g 1-oxa-3,8-diazaspiro[4.5]decan-2-one, 5.4 g 2,3-epoxypropyl-o-methoxyphenyl ether, 5 ml methanol and 10 ml toluene is heated at reflux for 24 hours. The solvent is evaporated and the residue filtered through 20 g silica gel with 10% methanol/methylene chloride. Evaporation of solvent and crystallization from diethyl ether affords 4.6 g 8-[3-(2-methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, mp 124°-125°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04244961 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-8c91b2a9954d4061a87269440b0d7ca5 |
| Source note | uspto-grants-1981_01 |