Hydrochloric Acid → HCID 20296606, compound

Participants

Reaction Steps

A mixture of 3.4 g 1-oxa-3,8-diazaspiro[4.5]decan-2-one, 2.26 g 2,3-epoxypropyl-p-methoxyphenyl ether, 5 ml methanol and 15 ml toluene is heated at reflux for 24 hours. Evaporation of solvent and recrystallization from ethyl acetate gives 2.7 g 8-[3-(4-methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, mp 151°-153°. To a solution of 1 g of 8-[3-(4-methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one in 5 ml methanol is added 10 ml of 3% hydrochloric acid in methanol. Addition of 200 ml diethyl ether, followed by filtration gives 8-[3-(4-methoxyphenoxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride, mp 198°-203°.

Provenance & Evidence