HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 20296598, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-((1-Naphthalenyloxy)methyl)oxirane | HCID 91521 | — |
| Reactant | 1-Oxa-3,8-diazaspiro(4.5)decan 2-one | HCID 12954114 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 20296598 | HCID 20296598 | 73.4% |
Reaction Steps
A mixture of 2 g 1-oxa-3,8-diazaspiro[4.5]-decan 2-one, 3.12 g 2,3-epoxypropyl 1-naphthyl ether, 5 ml methanol and 10 ml toluene is heated at reflux for 5 hours. The solvent is removed by evaporation in vacuum. The residue is filtered through 20 g silica gel with 5% methanol/methylene chloride. Evaporation of solvent and recrystalization from ethyl acetate affords 3.35 g 8-[3-(1-naphthyloxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, mp 178°-179°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04244961 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-28a56cb1a607482798621afa1bd1b3d2 |
| Source note | uspto-grants-1981_01 |