HCID 20551605, compound → HCID 13035411, compound

HRID 1389548Notes

Reaction equation

HRID 1389548 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:9][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]=C1C>[OH-].[Na+]>[NH2:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:9][NH:5][CH2:4][CH2:3][O:2][CH3:1]

Participants

3

Reactant 1

HCID 20551605HCID 20551605, compound

Product 1

HCID 13035411HCID 13035411, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ten grams of the methoxyethylmethylphenylimidazoline product of Example I is refluxed with 50 ml 30% aqueous sodium hydroxide solution for 24 hours. The mixture is then permitted to separate into two phases, and the aqueous layer is extracted with methylene chloride. The extract is concentrated and the resulting oil, which is identified as the intermediate amide, is refluxed with 20% aqueous sulfuric acid for six hours.

Workup

  1. customto separate into two phases
  2. extractionthe aqueous layer is extracted with methylene chloride
  3. concentrationThe extract is concentrated
  4. temperatureis refluxed with 20% aqueous sulfuric acid for six hours

Sources & evidence

ORD record
ord-3ff678058a72490a9cb5e4fa5b526d1c
Source dataset
uspto-grants-1981_01
Patent number
US04245102

Reaction notes

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