Hydrochloric Acid → HCID 136335637, compound

Participants

Reaction Steps

To a mixed solution of 1.65 g of sodium hydride (content 63%) and 15 ml of methanol were added 7.2 ml of 30% methylmercaptan in methanol and stirred at room temperature for 15 minutes. The solution was added dropwise to 4.289 g of 2-(3-bromopropionyl)-4-tert-butylphenol [described in Reference Example 3(h)] dissolved in 37.6 ml of tetrahydrofuran at room temperature and stirred at the same temperature for one hour. The reaction mixture was acidified with 1 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with water, and saturated brine successively, dried over sodium sulfate anhydride and concentrated at reduced pressure. The residue was chromatographed on silica gel column using a mixed solvent of cyclohexane and ethyl acetate (30:1) as an eluting agent to give 2.304 g of the title compound of the following physical properties as pale yellow oil.

Provenance & Evidence