Hydrogen Bromide → HCID 53983958, compound

Participants

Reaction Steps

1.56 g of the compound obtained in Example 3 (b) above was dissolved in 6 ml of acetic acid and 1.2 ml of 57% hydroiodic acid and 1.0 ml of 47% hydrobromic acid were added thereto, followed by heat-refluxing for 30 hours. The mixture was concentrated under reduced pressure, water was added to the residue and the mixture was extracted with ethyl acetate. The ethyl acetate extract was washed with water, dried, concentrated, and the residue was chromatographed on silica gel column using a mixed solvent of methylene chloride: ethyl acetate (20:1 by volume) as an eluting agent to obtain 510 mg of the title compound having the following properties.

Provenance & Evidence