Ammonia → HCID 178513906, compound

HRID 1389581Notes

Reaction equation

HRID 1389581 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]1[NH:14][CH2:13][CH2:12][N:11]1[O:15][CH2:16][CH2:17][CH2:18][C:19]([O:21]CC)=O.C[O-].[Na+].[NH3:27]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]1[NH:14][CH2:13][CH2:12][N:11]1[O:15][CH2:16][CH2:17][CH2:18][C:19]([NH2:27])=[O:21]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 10942334Sodium MethoxideHCID 178471737HCID 178471737, compound

Product 1

HCID 178513906HCID 178513906, compound

Procedure

5.51 g. of ethyl 4-{[2-[(2,6-dichlorophenyl)imino]-1-imidazolidinyl]oxy}butyrate, 200 mg. of sodium methylate and methanolic ammonia are warmed under pressure for 24 hours. The solution is then evaporated in vacuo. The residue is recrystallized from methylene chloride/diethyl ether and then from benzene/cyclohexane (1:1), whereupon 4-{[2-[(2,6-dichlorophenyl)imino]-1-imidazolidinyl]oxy}butyramide, m.p. 140°-141°, is obtained.

Workup

  1. customThe solution is then evaporated in vacuo
  2. customThe residue is recrystallized from methylene chloride/diethyl ether

Sources & evidence

ORD record
ord-1fa6358000074d369cf7cfce0ddbd596
Source dataset
uspto-grants-1981_01
Patent number
US04244957

Reaction notes

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