4-(2-Pyridylsulfinyl)butyric acid → 7-[4-(2-Pyridylsulfinyl)butyramido]-3-ethylthiomethyl-3-cephem-4-carboxylic acid

HRID 1389591Notes

Reaction equation

HRID 1389591 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=O)=[O:8].[NH2:15][CH:16]1[C:30](=[O:31])[N:18]2[C:19]([C:27]([OH:29])=[O:28])=[C:20]([CH2:23][S:24][CH2:25][CH3:26])[CH2:21][S:22][C@H:17]12>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([CH2:9][CH2:10][CH2:11][C:12]([NH:15][CH:16]1[C:30](=[O:31])[N:18]2[C:19]([C:27]([OH:29])=[O:28])=[C:20]([CH2:23][S:24][CH2:25][CH3:26])[CH2:21][S:22][C@H:17]12)=[O:14])=[O:8]

Participants

3

Reactant 2

HCID 202972034-(2-Pyridylsulfinyl)butyric acidHCID 677129017-Amino-3ethylthiomethyl-3-cephem-4-carboxylic acid

Product 1

HCID 1317120337-[4-(2-Pyridylsulfinyl)butyramido]-3-ethylthiomethyl-3-cephem-4-carboxylic acid

Procedure

426 mg. of 4-(2-pyridylsulfinyl)butyric acid and 7-amino-3-ethylthiomethyl-3-cephem-4-carboxylic acid were reacted in the same manner as described in Example 28 and 366 mg. of 7-[4-(2-pyridylsulfinyl)butyramido]-3-ethylthiomethyl-3-cephem-4-carboxylic acid were obtained.

Sources & evidence

ORD record
ord-af870090570d4510946d236eee57bd46
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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