3-(3-Thienylsulfinyl)butyric acid → 7-[3-(3-Thienylsulfinyl)butyramido]-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid

HRID 1389595Notes

Reaction equation

HRID 1389595 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([S:6]([CH:8]([CH3:13])[CH2:9][C:10]([OH:12])=O)=[O:7])=[CH:2]1.[NH2:14][CH:15]1[C:34](=[O:35])[N:17]2[C:18]([C:31]([OH:33])=[O:32])=[C:19]([C:22]([S:24][C:25]3[N:26]=[N:27][CH:28]=[CH:29][CH:30]=3)=[O:23])[CH2:20][S:21][C@H:16]12>>[S:1]1[CH:5]=[CH:4][C:3]([S:6]([CH:8]([CH3:13])[CH2:9][C:10]([NH:14][CH:15]2[C:34](=[O:35])[N:17]3[C:18]([C:31]([OH:33])=[O:32])=[C:19]([C:22]([S:24][C:25]4[N:26]=[N:27][CH:28]=[CH:29][CH:30]=4)=[O:23])[CH2:20][S:21][C@H:16]23)=[O:12])=[O:7])=[CH:2]1

Participants

3

Reactant 2

HCID 202971903-(3-Thienylsulfinyl)butyric acidHCID 1317120387-Amino-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid

Product 1

HCID 1317120377-[3-(3-Thienylsulfinyl)butyramido]-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid

Procedure

436 mg. of 3-(3-thienylsulfinyl)butyric acid and 7-amino-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid were reacted in the same manner as described in Example 28 and 432 mg. of 7-[3-(3-thienylsulfinyl)butyramido]-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid were obtained.

Sources & evidence

ORD record
ord-63707c03d3e44f939722f74be7229955
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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