2-Pyridylsulfinylacetic acid → 7-(2-Pyridylsulfinylacetamido)-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid

HRID 1389601Notes

Reaction equation

HRID 1389601 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([CH2:9][C:10]([OH:12])=O)=[O:8].[NH2:13][CH:14]1[C:33](=[O:34])[N:16]2[C:17]([C:30]([OH:32])=[O:31])=[C:18]([C:21]([S:23][C:24]3[N:25]=[N:26][CH:27]=[CH:28][CH:29]=3)=[O:22])[CH2:19][S:20][C@H:15]12>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([CH2:9][C:10]([NH:13][CH:14]1[C:33](=[O:34])[N:16]2[C:17]([C:30]([OH:32])=[O:31])=[C:18]([C:21]([S:23][C:24]3[N:25]=[N:26][CH:27]=[CH:28][CH:29]=3)=[O:22])[CH2:19][S:20][C@H:15]12)=[O:12])=[O:8]

Participants

3

Reactant 2

HCID 202971992-Pyridylsulfinylacetic acidHCID 1317120387-Amino-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid

Product 1

HCID 1317120447-(2-Pyridylsulfinylacetamido)-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid

Procedure

370 mg. of 2-pyridylsulfinylacetic acid and 7-amino-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid were reacted in the same manner as described in Example 28 and 341 mg. of 7-(2-pyridylsulfinylacetamido)-3-(1-oxopyridazine-3-ylthiomethyl)-3-cephem-4-carboxylic acid were obtained.

Sources & evidence

ORD record
ord-b4af50d7b9f14dceaf9c14670f7feaa0
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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