7-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid → HCID 70574011, compound

HRID 1389603Notes

Reaction equation

HRID 1389603 reaction equation
[N+:1]([C:4]1[O:5][C:6]([S:9]([CH2:11][C:12]([OH:14])=O)=[O:10])=[CH:7][CH:8]=1)([O-:3])=[O:2].[NH2:15][CH:16]1[C:34](=[O:35])[N:18]2[C:19]([C:31]([OH:33])=[O:32])=[C:20]([CH2:23][S:24][C:25]3[S:29][C:28]([CH3:30])=[N:27][N:26]=3)[CH2:21][S:22][C@H:17]12>>[N+:1]([C:4]1[O:5][C:6]([S:9]([CH2:11][C:12]([NH:15][CH:16]2[C:34](=[O:35])[N:18]3[C:19]([C:31]([OH:33])=[O:32])=[C:20]([CH2:23][S:24][C:25]4[S:29][C:28]([CH3:30])=[N:27][N:26]=4)[CH2:21][S:22][C@H:17]23)=[O:14])=[O:10])=[CH:7][CH:8]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 129420347-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acidHCID 20297230HCID 20297230, compound

Product 1

HCID 70574011HCID 70574011, compound

Procedure

438 mg. of 2-(2-nitrofuran-5-ylsulfinyl)acetic acid and 7-amino-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid were reacted in the same manner as described in Example 28 and 382 mg. of 7-[2-(2-nitrofuran-5-ylsulfinyl)acetamido]-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid were obtained.

Sources & evidence

ORD record
ord-41115ac660f54de7b5e267e3aa905bbd
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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