7-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid → HCID 70571569, compound

HRID 1389604Notes

Reaction equation

HRID 1389604 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]=1[S:10]([CH2:12][C:13]([OH:15])=O)=[O:11].[NH2:16][CH:17]1[C:35](=[O:36])[N:19]2[C:20]([C:32]([OH:34])=[O:33])=[C:21]([CH2:24][S:25][C:26]3[S:30][C:29]([CH3:31])=[N:28][N:27]=3)[CH2:22][S:23][C@H:18]12>>[N:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[NH:1][C:2]=1[S:10]([CH2:12][C:13]([NH:16][CH:17]1[C:35](=[O:36])[N:19]2[C:20]([C:32]([OH:34])=[O:33])=[C:21]([CH2:24][S:25][C:26]3[S:30][C:29]([CH3:31])=[N:28][N:27]=3)[CH2:22][S:23][C@H:18]12)=[O:15])=[O:11]

Participants

3

Reactant 2

HCID 129420347-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acidHCID 20297124HCID 20297124, compound

Product 1

HCID 70571569HCID 70571569, compound

Procedure

448 mg. of benzimidazol-2-ylsulfinylacetic acid and 7-amino-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid were reacted in the same manner as described in Example 28 and 161 mg. of 7-(benzimidazol-2-ylsulfinylacetamido)-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid were obtained.

Sources & evidence

ORD record
ord-7cfc2cbaa6734ea8a1512eb301fe833a
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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