(phenylsulfinyl)acetic acid → Methyl 7-(phenylsulfinylacetamido)-3-azidomethyl-3-cephem-4-carboxylate

HRID 1389605Notes

Reaction equation

HRID 1389605 reaction equation
[C:1]1([S:7]([CH2:9][C:10]([OH:12])=O)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:13][CH:14]1[C:29](=[O:30])[N:16]2[C:17]([C:25]([O:27][CH3:28])=[O:26])=[C:18]([CH2:21][N:22]=[N+:23]=[N-:24])[CH2:19][S:20][C@H:15]12>>[C:1]1([S:7]([CH2:9][C:10]([NH:13][CH:14]2[C:29](=[O:30])[N:16]3[C:17]([C:25]([O:27][CH3:28])=[O:26])=[C:18]([CH2:21][N:22]=[N+:23]=[N-:24])[CH2:19][S:20][C@H:15]23)=[O:12])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 233599(phenylsulfinyl)acetic acidHCID 131712047Methyl 7-amino-3-azidomethyl-3-cephem-4-carboxylate

Product 1

HCID 131712046Methyl 7-(phenylsulfinylacetamido)-3-azidomethyl-3-cephem-4-carboxylate

Procedure

368 mg. of phenylsulfinylacetic acid and methyl 7-amino-3-azidomethyl-3-cephem-4-carboxylate were reacted in the same manner as described in Example 4 and 503 mg. of methyl 7-(phenylsulfinylacetamido)-3-azidomethyl-3-cephem-4-carboxylate were obtained.

Sources & evidence

ORD record
ord-131d03301196481e8890602195bf7113
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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