3-Carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acid → HCID 131712049, compound

HRID 1389607Notes

Reaction equation

HRID 1389607 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH:10]([CH3:14])[C:11]([OH:13])=O)=[O:9])=[CH:4][CH:3]=1.[NH2:15][CH:16]1[C:31](=[O:32])[N:18]2[C:19]([C:28]([OH:30])=[O:29])=[C:20]([CH2:23][O:24][C:25](=[O:27])[NH2:26])[CH2:21][S:22][C@H:17]12>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH:10]([CH3:14])[C:11]([NH:15][CH:16]2[C:31](=[O:32])[N:18]3[C:19]([C:28]([OH:30])=[O:29])=[C:20]([CH2:23][O:24][C:25](=[O:27])[NH2:26])[CH2:21][S:22][C@H:17]23)=[O:13])=[O:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 127847593-Carbamoyloxymethyl-7-amino-3-cephem-4-carboxylic acidHCID 20297096HCID 20297096, compound

Product 1

HCID 131712049HCID 131712049, compound

Procedure

428 mg. of 2-(p-hydroxyphenylsulfinyl)propionic acid and 7-amino-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid were reacted in the same manner as described in Example 28 and 131 mg. of 7-[2-(p-hydroxyphenylsulfinyl)propionamido]-3-carbamoyloxymethyl-3-cephem-4-carboxylic acid were obtained.

Sources & evidence

ORD record
ord-f23cc07a6a48432da5fbb8f70a398ad7
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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