7-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid → HCID 131712051, compound

HRID 1389609Notes

Reaction equation

HRID 1389609 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH:10]([CH2:15][CH3:16])[CH2:11][C:12]([OH:14])=O)=[O:9])=[CH:4][CH:3]=1.[NH2:17][CH:18]1[C:36](=[O:37])[N:20]2[C:21]([C:33]([OH:35])=[O:34])=[C:22]([CH2:25][S:26][C:27]3[S:31][C:30]([CH3:32])=[N:29][N:28]=3)[CH2:23][S:24][C@H:19]12>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH:10]([CH2:15][CH3:16])[CH2:11][C:12]([NH:17][CH:18]2[C:36](=[O:37])[N:20]3[C:21]([C:33]([OH:35])=[O:34])=[C:22]([CH2:25][S:26][C:27]4[S:31][C:30]([CH3:32])=[N:29][N:28]=4)[CH2:23][S:24][C@H:19]23)=[O:14])=[O:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 129420347-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acidHCID 20297162HCID 20297162, compound

Product 1

HCID 131712051HCID 131712051, compound

Procedure

484 mg. of 3-(p-hydroxyphenylsulfinyl)pentanoic acid and 7-amino-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid were reacted in the same manner as described in Example 28 and 555 mg. of 7-[3-(p-hydroxyphenylsulfinyl)pentanamido]-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid were obtained.

Sources & evidence

ORD record
ord-0cce2502f80e46c2a8e4f8dfe10ca9e0
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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