7-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acid → HCID 131712053, compound

HRID 1389611Notes

Reaction equation

HRID 1389611 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH:10]([CH3:15])[CH2:11][C:12]([OH:14])=O)=[O:9])=[CH:4][CH:3]=1.[NH2:16][CH:17]1[C:35](=[O:36])[N:19]2[C:20]([C:32]([OH:34])=[O:33])=[C:21]([CH2:24][S:25][C:26]3[S:30][C:29]([CH3:31])=[N:28][N:27]=3)[CH2:22][S:23][C@H:18]12>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([CH:10]([CH3:15])[CH2:11][C:12]([NH:16][CH:17]2[C:35](=[O:36])[N:19]3[C:20]([C:32]([OH:34])=[O:33])=[C:21]([CH2:24][S:25][C:26]4[S:30][C:29]([CH3:31])=[N:28][N:27]=4)[CH2:22][S:23][C@H:18]23)=[O:14])=[O:9])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 129420347-Amino-3-(5-methyl-1,3,4-thiadiazol-2-yl)thiomethyl-3-cephem-4-carboxylic acidHCID 20297250HCID 20297250, compound

Product 1

HCID 131712053HCID 131712053, compound

Procedure

456 mg. of 3-(p-hydroxyphenylsulfinyl)butyric acid and 7-amino-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid were reacted in the same manner as described in Example 28 and 400 mg. of 7-[3-(p-hydroxyphenylsulfinyl)butyramido]-3-(2-methyl-1,3,4-thiadiazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid were obtained.

Sources & evidence

ORD record
ord-90d2afd6e3d649abafb7a8e0699753fa
Source dataset
uspto-grants-1981_01
Patent number
US04245107

Reaction notes

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