HCID 20297259, compound → Fenoprofen

Participants

Reaction Steps

1.11 g (3.17 mmols) of 2-phenylthio-2-(3-phenoxyphenyl)propionic acid obtained in Example 6 was dissolved in 10 ml of acetic acid and the solution was heated while refluxing for 1 hour with stirring in the presence of 1.0 g of zinc powder. The solid substance present in the reaction mixture was removed by filtration and washed with methylene chloride. The combined filtrate and washing was concentrated to obtain 0.86 g of a crude product which was then purified by silica gel column chromatography eluting with diethyl etherhexane (1:5 by volume) to obtain 0.73 g (95% yield) of 2-(3-phenoxyphenyl)propionic acid. nD26 1.5780.

Provenance & Evidence