Phthalic Anhydride → HCID 70540397, compound

HRID 1389674Notes

Reaction equation

HRID 1389674 reaction equation
C(N(CC)CC)C.[S:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][C:14]([NH:16][C@@H:17]1[C:29](=[O:30])[N:19]2[C:20]([C:26]([OH:28])=[O:27])=[C:21]([CH2:24][OH:25])[CH2:22][S:23][C@H:18]12)=[O:15].[C:31]1(=[O:41])[O:36][C:34](=[O:35])[C:33]2=[CH:37][CH:38]=[CH:39][CH:40]=[C:32]12>ClCCl>[S:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][C:14]([NH:16][C@@H:17]1[C:29](=[O:30])[N:19]2[C:20]([C:26]([OH:28])=[O:27])=[C:21]([CH2:24][O:25][C:31](=[O:41])[C:32]3[CH:40]=[CH:39][CH:38]=[CH:37][C:33]=3[C:34]([OH:36])=[O:35])[CH2:22][S:23][C@H:18]12)=[O:15]

Participants

4

Reactant 2

HCID 6811Phthalic AnhydrideHCID 70542398HCID 70542398, compound

Product 1

HCID 70540397HCID 70540397, compoundYield 86.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In dichloromethane (25 ml) was dissolved 7β-(2-thienylacetamido)-3-hydroxymethyl-3-cephem-4-carboxylic acid triethylamine salt (3.60 g), followed by addition of phthalic anhydride (1.80 g). The mixture was stirred at room temperature for 2 hours, after which time it was treated in a manner similar to that described in Example 8. The procedure provided 7β-(2-thienylacetamido)-3-(2-carboxybenzoyloxy)methyl-3-cephem-4-carboxylic acid (3.44 g).

Workup

  1. additionafter which time it was treated in a manner similar to

Sources & evidence

ORD record
ord-8bc1ed2ff7b54a2b8e5a019ff761f417
Source dataset
uspto-grants-1981_01
Patent number
US04245088

Reaction notes

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