4-Toluenesulfonyl chloride → HCID 53697721, compound

Participants

Reaction Steps

A suspension of the product (16.7 g) of Stage 1 in pyridine (100 ml) was treated with p-toluene sulphonyl chloride (11 g) and shaken vigorously. The mixture was allowed to stand for 8 days with occasional shaking, during which time the solid dissolved and a dark red solution was obtained. The solution was then quenched with 2 N-hydrochloric acid (500 ml) and the resultant solid filtered off, washed with water and dried. Crystallization from petroleum ether gave the title product (15.4 g; 97%), m.p. 140°-140.5°.

Provenance & Evidence