Methyl iodide → HCID 20295269, compound

HRID 1389755Notes

Reaction equation

HRID 1389755 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][CH2:10][CH2:11][NH:12][CH2:13][CH2:14][CH:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:4][CH:3]=1.[CH3:28]I>CO>[CH3:28][N:12]([CH2:13][CH2:14][CH:15]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:11][CH2:10][CH2:9][S:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 20295254HCID 20295254, compound

Product 1

HCID 20295269HCID 20295269, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.8 g (0.0021 moles) of N-(3'-p-hydroxyphenylthiopropyl)-3,3-diphenylpropylamine in 20 ml methanol containing 0.3 ml triethylamine are gradually added 0.13 ml (0.0021 moles) methyl iodide. After 36 hours at room temperature the solvent is evaporated under vacuum and the residue is dissolved in 20 ml benzene. The solution is washed three times with water, dried and evaporated.

Workup

  1. customAfter 36 hours at room temperature the solvent is evaporated under vacuum
  2. dissolutionthe residue is dissolved in 20 ml benzene
  3. washThe solution is washed three times with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-78edeadd51ef407d9742aecd9e413661
Source dataset
uspto-grants-1981_01
Patent number
US04246201

Reaction notes

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