HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-((1-Benzylpiperidin-4-yl)oxy)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-Benzyl-4-(carbethoxymethoxy)-piperidine | HCID 20295373 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-((1-Benzylpiperidin-4-yl)oxy)ethanol | HCID 20295347 | — |
Reaction Steps
A solution of (A) (14 g) in tetrahydrofuran (50 ml) was added to a solution of lithium aluminum hydride (2 g) in tetrahydrofuran (100 ml) under stirring. The mixture was refluxed for 3 hours and finally hydrolyzed by careful addition of water. After removal of inorganic salts by filtration, the filtrate was concentrated to give (B) as a viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04246262 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-111e5e2951ff4b44a9d5bbc0ede53467 |
| Source note | uspto-grants-1981_01 |