HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 4-(2'-Hydroxyethoxy)-piperidine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 2-((1-Benzylpiperidin-4-yl)oxy)ethanol | HCID 20295347 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(2'-Hydroxyethoxy)-piperidine hydrobromide | HCID 20295331 | — |
Reaction Steps
A solution of (B) (12 g) in ethanol (200 ml) was neutralized with an ethanolic solution of hydrogen bromide and hydrogenated in the presence of 10% palladium on carbon (2.4 g). After 5 hours the uptake of hydrogen ceased and the catalyst was removed by filtration. The filtrate was taken to dryness in vacuo to give (C) as a semicrystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04246262 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-939c151a292345a6892d6121f3d4fa37 |
| Source note | uspto-grants-1981_01 |