2-(Diethylamino)ethanethiol → HCID 20295352, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N,N-diethylaminoethylmercaptan (4 g, 0.03 mole) in methanol (10 ml), 5 N potassium hydroxide in methanol (5 ml) was added, followed by (B) (5.5 g, 0.025 mole). The mixture was heated to 40° C. for 20 hours. After removal of the solvent in vacuo, the residue was diluted with ether (50 ml) and filtered. The filtrate was washed with two 5 ml portions of 2 N sodium hydroxide followed by water and dried. The solvent was stripped in vacuo, and the residue was chromatographed on "Florisil" (100 g), eluting with ether followed by ethyl acetate-methanol (8:2) to give (C) as a faintly yellow oil.

Provenance & Evidence