反应详情

To a solution of (A) (5.3 g, 0.03 mole) in methanol (10 ml), 5 N potassium hydroxide in methanol (5 ml) was added, followed by N-formyl-4-bromomethylpiperidine (5.2 g, 0.025 mole). The mixture was left at room temperature for 20 hours. After removal of the solvent in vacuo, the residue was diluted with ether (50 ml) and filtered. The filtrate was washed with two 5 ml portions of 2 N sodium hydroxide, followed by water and dried. The solvent was stripped in vacuo, and the residue was chromatographed on silica gel (100 g), eluting with ether to give (B) as a colourless oil.

1. customAfter removal of the solvent in vacuo
2. additionthe residue was diluted with ether (50 ml)
3. filtrationfiltered
4. washThe filtrate was washed with two 5 ml portions of 2 N sodium hydroxide
5. customdried
6. customthe residue was chromatographed on silica gel (100 g)
7. washeluting with ether