HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 1-([1,1'-Biphenyl]-4-yl)-2-(1H-imidazol-1-yl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 1-(1,1'-Biphenyl)-4-yl-2-bromoethanone | HCID 67282 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-([1,1'-Biphenyl]-4-yl)-2-(1H-imidazol-1-yl)ethan-1-one | HCID 51709 | 65.4% |
Reaction Steps
39 g (0.14 mol) of 4-phenylphenacyl bromide are introduced in portions into a solution of 48.2 g (0.7 mol) of imidazole in 140 ml of dimethylformamide, whilst cooling. The mixture is allowed to subsequently react for 15 hours and the solution is poured into water. The crystal mass which has separated out is recrystallised from ethanol. 24 g (65% of theory) of 4-biphenylyl imidazol-1-yl-methyl ketone of melting point 198° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04246274 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-30f59f05e9d541cc8c788b4ef056d9b6 |
| Source note | uspto-grants-1981_01 |