Imidazole → HCID 13013629, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 39.8 g (0.1 mol) of 2-(4-cyclohexylphenyl)-3-chloro-1-(2,4-dichlorophenyl)-propan-2-ol in 200 ml of acetonitrile is added dropwise to a suspension of 3.6 g (0.12 mol) of sodium hydride and 8.2 g (0.12 mol) of imidazole in 200 ml of acetonitrile. After heating the mixture to 80° C. for three hours, it is filtered and the crystal mass is washed with water and recrystallised from acetonitrile. 24.9 g (58% of theory) of 2-(4-cyclohexylphenyl)-1-(2,4-dichlorophenyl)-3-(imidazol-1-yl)-propan-2-ol of melting point 142° C. are obtained.

Provenance & Evidence