Thiophenol → HCID 86736580, compound

HRID 1389847Notes

Reaction equation

HRID 1389847 reaction equation
[O:1]1[CH:7]2[CH:2]1[CH2:3][N:4]([C:8]([O:10][CH2:11][C:12]([Cl:15])([Cl:14])[Cl:13])=[O:9])[CH2:5][CH2:6]2.[C:16]1([SH:22])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[OH-].[Na+]>C(#N)C>[OH:1][C@H:2]1[C@H:7]([S:22][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:6][CH2:5][N:4]([C:8]([O:10][CH2:11][C:12]([Cl:15])([Cl:14])[Cl:13])=[O:9])[CH2:3]1

Participants

5

Reactant 3

HCID 7969ThiophenolHCID 14798Sodium HydroxideHCID 20548869HCID 20548869, compound

Product 1

HCID 86736580HCID 86736580, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

40 g (0.146 mol) of the 3,4-epoxy-1-(β,β,β-trichloroethoxycarbonyl)-piperidine obtained according to Example 12 are dissolved, together with 32 g (0.29 mol) of thiophenol and 146 ml (0.29 mol) of 2 N sodium hydroxide solution, in 300 ml of acetonitrile. The reaction mixture is heated under reflux for 4 hours, then cooled to room temperature and concentrated to about 1/3 of the original volume under a water pump vacuum. The solution is then diluted with 900 ml of water and extracted by shaking with 3 times 1,000 ml of methylene chloride; the combined organic phases are washed twice with 0.1 N sodium hydroxide solution and then with water, dried over sodium sulphate and evaporated under a water pump vacuum. The oil which remains is dissolved in 50 ml of benzene and the solution is filtered through a layer of silica gel. Trans-3-hydroxy-4-phenylthio-1-(β,β,β-trichloroethoxycarbonyl)-piperidine is isolated in the form of a slightly orange coloured oil by elution with a benzene/ethyl acetate mixture (4:1).

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureunder reflux for 4 hours
  3. concentrationconcentrated to about 1/3 of the original volume under a water pump vacuum
  4. additionThe solution is then diluted with 900 ml of water
  5. extractionextracted
  6. washthe combined organic phases are washed twice with 0.1 N sodium hydroxide solution
  7. dry with materialwith water, dried over sodium sulphate
  8. customevaporated under a water pump vacuum
  9. dissolutionThe oil which remains is dissolved in 50 ml of benzene
  10. filtrationthe solution is filtered through a layer of silica gel

Sources & evidence

ORD record
ord-0f396a76b07e4a039580e7c845d64d6e
Source dataset
uspto-grants-1981_01
Patent number
US04246269

Reaction notes

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