4-Bromo-1-naphthyl 4-piperidyl ketone → alpha(4-Bromo-1-naphthyl)-4-piperidinemethanol

HRID 1389865Notes

Reaction equation

HRID 1389865 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12]([Br:19])=[CH:11][CH:10]=2)=[O:8])[CH2:3][CH2:2]1.Cl.N1CCC(C(C2C=CC3C(=CC=C(Cl)C=3)C=2)=O)CC1>>[Br:19][C:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]([CH:7]([CH:4]2[CH2:3][CH2:2][NH:1][CH2:6][CH2:5]2)[OH:8])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 538693784-Bromo-1-naphthyl 4-piperidyl ketoneHCID 705701616-Chloro-2-naphthyl 4-piperidyl ketone hydrochloride

Product 1

HCID 20295554alpha(4-Bromo-1-naphthyl)-4-piperidinemethanol

Procedure

When in the procedure of Example 9, 4-bromo-1-naphthyl 4-piperidyl ketone is substituted for 6-chloro-2-naphthyl 4-piperidyl ketone hydrochloride, α(4-bromo-1-naphthyl)-4-piperidinemethanol is obtained.

Sources & evidence

ORD record
ord-3f288e8cbef644fe9254cd7dddac7a9a
Source dataset
uspto-grants-1981_01
Patent number
US04246268

Reaction notes

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