HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluorobenzoyl)propyl chloride → 4-[4-(1-Naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluorobenzoyl)propyl chloride | HCID 19750 | — |
| Reactant | 4-Chlorobutyrophenone | HCID 253533 | — |
| Reactant | 1-Naphthyl 4-piperidyl ketone hydrochloride | HCID 20295536 | — |
| Reactant | 2-Naphthyl 4-piperidyl ketone hydrochloride | HCID 20295547 | — |
| Product | 4-[4-(1-Naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone hydrochloride | HCID 20295551 | — |
Reaction Steps
When in the procedure of Example 19, 4-chloro-1-(4-fluorophenyl)-1-butanone is substituted for 4-chloro-1-phenyl-1-butanone and 1-naphthyl 4-piperidyl ketone hydrochloride is substituted for 2-naphthyl 4-piperidyl ketone hydrochloride, 4-[4-(1-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone hydrochloride is produced. M.P. 239°-41°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04246268 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-d6e490c97602450099a8464385dc4e98 |
| Source note | uspto-grants-1981_01 |